Napon C, Kaboré A, Ouédraogo M, Dravé A, Lompo L, Kaboré J
CHU Yalgado Ouédraogo, service de neurologie, BP 7022, Ouagadougou 03, Burkina Faso, Côte d'Ivoire.
Med Sante Trop. 2012 Oct-Dec;22(4):390-3. doi: 10.1684/mst.2012.0107.
S and C hemoglobinopathies are a group of inherited blood disorders including sickle cell disease, characterized by the presence of abnormal S and C hemoglobins. They are common in tropical Africa. Stroke is a common complication of sickle cell disease. Studies of the relation between these two diseases are virtually nonexistent in sub-saharan Africa. Our work aimed to study the influence of these hemoglobinopathies on the onset of strokes in adults. This cross-sectional study took place from 1st December 2009 to 31st May 2010 at University Hospital Yalgado Ouedraogo. Out of 142 patients admitted to our neurology department during this period, 74 patients had had strokes. Their mean age was 55.9 years and their sex ratio 1.53. Ischemic strokes accounted for 57% of the total, followed by cerebral hemorrhage (39%). Forty-six patients (62%) were AA genotype, 27 (36%) patients had sickle cell trait (16 AC and 11 AS) and three patients were homozygous CC. This study showed a higher prevalence of hemoglobinopathies in patients with stroke than in the general population. Unlike heterozygous SC and homozygous SS forms, the existence of sickle cell trait in this population does not appear to increase the risk of onset of ischemic stroke but may reduce the age at onset of cerebral hemorrhage.
S和C血红蛋白病是一组遗传性血液疾病，包括镰状细胞病，其特征是存在异常的S和C血红蛋白。它们在热带非洲很常见。中风是镰状细胞病的常见并发症。在撒哈拉以南非洲，关于这两种疾病之间关系的研究几乎不存在。我们的工作旨在研究这些血红蛋白病对成年人中风发病的影响。这项横断面研究于2009年12月1日至2010年5月31日在亚尔加杜·乌德拉奥果大学医院进行。在此期间，我们神经科收治的142例患者中，74例发生了中风。他们的平均年龄为55.9岁，性别比为1.53。缺血性中风占总数的57%，其次是脑出血（39%）。46例患者（62%）为AA基因型，27例患者（36%）有镰状细胞性状（16例AC和11例AS），3例患者为纯合子CC。这项研究表明，中风患者中血红蛋白病的患病率高于一般人群。与杂合子SC和纯合子SS形式不同，该人群中镰状细胞性状的存在似乎不会增加缺血性中风的发病风险，但可能会降低脑出血的发病年龄。
