Teepe R G, Koebrugge E J, Zeeman R J, van der Rhee H J, Vermeer B J
Afd. Huidziekten, Academisch Ziekenhuis, Leiden.
Ned Tijdschr Geneeskd. 1990 Apr 14;134(15):750-4.
In 18 patients with 25 chronic stasis ulcers and in 15 patients with 22 chronic leg ulcers of different aetiology, and in 7 patients with a variety of skin defects the effect of cryopreserved cultured allografts (CPA) on wound healing was investigated. The ulcers were grafted weekly or every other week on an outpatient basis until healing occurred. In 78% of the patients with stasis ulcers (84% of the ulcers) there was complete healing with a mean healing time of 31 days and a mean healing rate of 4.9 cm2 per week. The mean healing time of arterial and rheumatoid ulcers was 68 days and 56 days, respectively, while donor sites and erosive skin lesions all healed within 5 days. Five ulcers (9%), including one stasis ulcer, in 5 patients showed no change. We conclude that CPA is an easily applicable and effective biological product that profoundly stimulates the host epithelialisation, reduces the pain and is specifically effective in accelerating the healing of chronic stasis ulcers and donor sites.
对18例患有25处慢性淤滞性溃疡的患者、15例患有22处不同病因慢性腿部溃疡的患者以及7例有各种皮肤缺损的患者，研究了深低温保存的培养同种异体移植物（CPA）对伤口愈合的影响。溃疡每周或每隔一周在门诊进行移植，直至愈合。在患有淤滞性溃疡的患者中，78%（溃疡的84%）实现了完全愈合，平均愈合时间为31天，平均愈合速度为每周4.9平方厘米。动脉性溃疡和类风湿性溃疡的平均愈合时间分别为68天和56天，而供区和糜烂性皮肤病变均在5天内愈合。5例患者中的5处溃疡（9%），包括1处淤滞性溃疡，无变化。我们得出结论，CPA是一种易于应用且有效的生物制品，能显著刺激宿主上皮形成，减轻疼痛，对加速慢性淤滞性溃疡和供区的愈合特别有效。
