应用冷冻保存的同种异体培养上皮治疗腿部溃疡。一项多中心研究。
Treatment of leg ulcers with cryopreserved allogeneic cultured epithelium. A multicenter study.
作者信息
De Luca M, Albanese E, Cancedda R, Viacava A, Faggioni A, Zambruno G, Giannetti A
机构信息
National Institute for Cancer Research, Laboratory of Cell Differentiation, Genoa, Italy.
出版信息
Arch Dermatol. 1992 May;128(5):633-8.
BACKGROUND
In the past few years, several authors have described the usefulness of cultured allogeneic epidermal sheets in promoting wound healing of burns, leg ulcers, and donor sites. This study reports clinical results obtained by different departments in the treatment of chronic leg ulcers by cryopreserved cultured allogeneic epithelium. The freezing procedure and the assessment of viability of the cryopreserved epithelium are also described. A total of 30 ulcers were treated using 138 cryopreserved allografts.
OBSERVATIONS
Twenty ulcers (66.6%) healed completely within 12 weeks. Four ulcers showed a 30% to 84.4% reduction in size by 3 weeks but did not heal completely; the remaining six ulcers did not show any improvement. A strong stimulation of granulation tissue formation and of reepithelialization from the wound edge were observed.
RESULTS
The results indicate that frozen cultured epidermis, stored in a skin bank, is a valid and generally applicable alternative therapy for the treatment of chronic ulcers.
背景
在过去几年中，几位作者描述了培养的同种异体表皮片在促进烧伤、腿部溃疡和供皮区伤口愈合方面的作用。本研究报告了不同科室使用冷冻保存的培养同种异体上皮治疗慢性腿部溃疡的临床结果。还描述了冷冻程序以及冷冻保存上皮的活力评估。共使用138块冷冻保存的同种异体移植物治疗了30处溃疡。
观察结果
20处溃疡（66.6%）在12周内完全愈合。4处溃疡在3周时面积缩小了30%至84.4%，但未完全愈合；其余6处溃疡没有任何改善。观察到对肉芽组织形成和伤口边缘再上皮化有强烈刺激作用。
结果
结果表明，储存在皮肤库中的冷冻培养表皮是治疗慢性溃疡的一种有效且普遍适用的替代疗法。
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