Verdecchia Paolo, Angeli Fabio
Dipartimento Malattie Cardiovascolari, Ospedale R. Silvestrini, Località Ponte della Pietra, 06100, Perugia, Italy,
High Blood Press Cardiovasc Prev. 2005 Sep;12(3):119-24. doi: 10.2165/00151642-200512030-00002.
A reduction in blood pressure (BP) levels is the most important mechanism accounting for the reduction in cardiovascular complications induced by treatment. However, results of recent clinical trials and meta-analyses have shown that antihypertensive drugs possess important ancillary properties that might play an additional role in the prevention of cardiovascular disease.Reviewing the literature, ACE inhibitors seem to have ancillary properties that can contribute to influence the risk of coronary artery disease with mechanisms partially independent of BP reduction.On the other hand, dihydropyridine calcium channel blockers, such as amlodipine, have been proven to lower the incidence of stroke but their use seems to be effective in relieving symptoms of coronary artery disease and reducing the rate of revascularisation procedures.
血压（BP）水平降低是治疗所致心血管并发症减少的最重要机制。然而，近期临床试验和荟萃分析结果表明，抗高血压药物具有重要的辅助特性，可能在预防心血管疾病中发挥额外作用。回顾文献，血管紧张素转换酶（ACE）抑制剂似乎具有辅助特性，可通过部分独立于血压降低的机制影响冠状动脉疾病风险。另一方面，二氢吡啶类钙通道阻滞剂，如氨氯地平，已被证明可降低中风发生率，但其使用似乎在缓解冠状动脉疾病症状和降低血运重建手术率方面有效。
