Remeijer L, van Rij G, Beekhuis W H, Polak B C, van Nes J
Department of Ophthalmology, Erasmus University, Eye Hospital, Rotterdam, The Netherlands.
Ophthalmology. 1990 Mar;97(3):281-5. doi: 10.1016/s0161-6420(90)32591-5.
In 32 patients with long-term contact lens wear (up to 19 years), deep whitish opacities directly adjacent to Descemet's membrane were seen in the central part of the cornea. These opacities were seen in soft hydroxyethylmethacrylate (HEMA) as well as in hard (polymethylmethacrylate, PMMA) contact lens wear. These conditions could reduce visual acuity. When contact lens wear was discontinued or when the HEMA or PMMA lenses were replaced by gas-permeable rigid lenses, the lesions gradually diminished and resolved completely in most patients. One possible cause of these opacities is an allergic reaction to thimerosal. Another possible cause is chronic anoxia of the corneal stroma and endothelium. Endothelial cell density was not abnormal, but there was a marked polymegethism of the endothelium as a sign of endothelial stress.
在32名长期佩戴隐形眼镜（长达19年）的患者中，在角膜中央可见紧邻后弹力层的深层白色混浊。软性甲基丙烯酸羟乙酯（HEMA）和硬性（聚甲基丙烯酸甲酯，PMMA）隐形眼镜佩戴者中均可见到这些混浊。这些情况可能会降低视力。当停止佩戴隐形眼镜或用透气硬性镜片取代HEMA或PMMA镜片时，大多数患者的病变会逐渐减轻并完全消退。这些混浊的一个可能原因是对硫柳汞的过敏反应。另一个可能原因是角膜基质和内皮的慢性缺氧。内皮细胞密度并无异常，但内皮有明显的大小不均，这是内皮应激的迹象。
