明尼苏达双胞胎与家庭研究中心全基因组关联研究。
The Minnesota Center for Twin and Family Research genome-wide association study.
作者信息
Miller Michael B, Basu Saonli, Cunningham Julie, Eskin Eleazar, Malone Steven M, Oetting William S, Schork Nicholas, Sul Jae Hoon, Iacono William G, McGue Matt
机构信息
Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
出版信息
Twin Res Hum Genet. 2012 Dec;15(6):767-74. doi: 10.1017/thg.2012.62.
Abstract
As part of the Genes, Environment and Development Initiative, the Minnesota Center for Twin and Family Research (MCTFR) undertook a genome-wide association study, which we describe here. A total of 8,405 research participants, clustered in four-member families, have been successfully genotyped on 527,829 single nucleotide polymorphism (SNP) markers using lllumina's Human660W-Ouad array. Quality control screening of samples and markers as well as SNP imputation procedures are described. We also describe methods for ancestry control and how the familial clustering of the MCTFR sample can be accounted for in the analysis using a Rapid Feasible Generalized Least Squares algorithm. The rich longitudinal MCTFR assessments provide numerous opportunities for collaboration.
摘要
作为基因、环境与发育计划的一部分，明尼苏达双胞胎与家庭研究中心（MCTFR）开展了一项全基因组关联研究，我们在此对其进行描述。共有8405名研究参与者，以四人家庭为单位进行分组，使用Illumina公司的Human660W-Quad芯片成功对527829个单核苷酸多态性（SNP）标记进行了基因分型。文中描述了样本和标记的质量控制筛选以及SNP填充程序。我们还描述了血统控制方法，以及如何在分析中使用快速可行广义最小二乘法算法来考虑MCTFR样本的家族聚类情况。丰富的MCTFR纵向评估提供了众多合作机会。
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