Department of Dermatology, University of Athens Medical School, Athens, Greece.
J Cutan Med Surg. 2013 Jan-Feb;17(1):52-4. doi: 10.2310/7750.2012.12022.
Cutaneous xanthomas develop as a result of intracellular and dermal deposition of lipids in either hyper- or normolipidemic patients. Plane xanthomas may signal the presence of an underlying monoclonal gammopathy, chronic myelomonocytic leukemia, or cutaneous T-cell lymphoma. Investigators have suggested that xanthomatized T cells may result in induction of plane xanthomas.
We report the case of a patient with mycosis fungoides (MF) and plane xanthomas who was treated with bexarotene for his MF.
Significant improvement in the clinical signs of MF was observed within 3 months. We also observed a substantial regression of the xanthomas after 5 months of treatment. Complete clinical remission of both the MF and xanthomas was obtained after 6 months. The patient was still free of xanthomas after 3 years of follow-up.
Bexarotene led to the clearing of the cutaneous lesions of cutaneous T-cell lymphoma and plane xanthomas. This may be due to an effect of bexarotene on the aberrant T cells that may cause xanthomatization.
皮肤黄色瘤是由于细胞内和真皮中脂质沉积在高脂血症或正常血脂患者中形成的。平面黄色瘤可能表明存在潜在的单克隆丙种球蛋白病、慢性髓单核细胞白血病或皮肤 T 细胞淋巴瘤。研究人员认为，黄色瘤化 T 细胞可能导致平面黄色瘤的发生。
我们报告了一例蕈样肉芽肿（MF）伴平面黄色瘤的患者，他接受了贝沙罗汀治疗 MF。
在 3 个月内观察到 MF 的临床体征明显改善。我们还观察到治疗 5 个月后黄色瘤明显消退。经过 6 个月的治疗，MF 和黄色瘤均获得完全临床缓解。在 3 年的随访中，患者仍无黄色瘤。
贝沙罗汀导致皮肤 T 细胞淋巴瘤和平面黄色瘤的皮肤病变清除。这可能是由于贝沙罗汀对导致黄色瘤化的异常 T 细胞的作用。
