Department of Dermatology, Gazi University School of Medicine, Ankara, Turkey.
J Coll Physicians Surg Pak. 2021 Jun;31(6):716-718. doi: 10.29271/jcpsp.2021.06.716.
Mycosis fungoides (MF) is a skin lymphoma characterised by atypical T lymphocyte infiltration, which may present with patches and tumors in advanced stages. Treatment options in MF aim to reduce symptoms, since patients usually do not achieve complete cure. Bexarotene is used for treatment-resistant early stage MF and advanced stages of the disease. It has been suggested that white blood cell (WBC)/absolute lymphocyte count, WBC, absolute lymphocyte and eosinophil counts might be prognostic factors in MF. Therefore, we investigated the changes in complete blood count (CBC) parameters and CBC-derived inflammatory biomarkers in patients with MF treated with bexarotene. The results revealed that neutrophil (NE)%, NE numbers, neutrophil/lymphocyte, derived neutrophil/lymphocyte, (neutrophil × monocytes)/lymphocyte and (neutrophils × monocytes × platelets)/lymphocyte counts decreased in all patients three months after bexarotene treatment. We suggest that these inflammatory biomarkers can be used in the follow-up of patients with MF receiving bexarotene treatment. Moreover, these results indicate that decrease in these inflammatory biomarkers may signify improvement of the disease. Key Words: Bexarotene, İnflammatory biomarkers, Mycosis fungoides.
蕈样肉芽肿（MF）是一种以非典型 T 淋巴细胞浸润为特征的皮肤淋巴瘤，在晚期可能表现为斑块和肿瘤。MF 的治疗目标是减轻症状，因为患者通常无法实现完全治愈。贝沙罗汀用于治疗耐药的早期 MF 和疾病的晚期。已经有研究表明，白细胞（WBC）/绝对淋巴细胞计数、WBC、绝对淋巴细胞和嗜酸性粒细胞计数可能是 MF 的预后因素。因此，我们研究了用贝沙罗汀治疗 MF 患者的全血细胞计数（CBC）参数和 CBC 衍生的炎症生物标志物的变化。结果表明，所有患者在接受贝沙罗汀治疗 3 个月后，中性粒细胞（NE）%、NE 计数、中性粒细胞/淋巴细胞、衍生中性粒细胞/淋巴细胞、（中性粒细胞×单核细胞）/淋巴细胞和（中性粒细胞×单核细胞×血小板）/淋巴细胞计数均降低。我们建议，这些炎症生物标志物可用于接受贝沙罗汀治疗的 MF 患者的随访。此外，这些结果表明，这些炎症生物标志物的减少可能表明疾病的改善。
贝沙罗汀、炎症生物标志物、蕈样肉芽肿。
