Department of Dermatology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
J Cutan Med Surg. 2013 Jan-Feb;17(1):55-61. doi: 10.2310/7750.2012.12033.
Radiation- and chemotherapy-induced alopecia is mostly temporary. However, permanent scalp alopecia is reported, albeit infrequently.
The objective of this observational case series was to determine the kind and doses of chemotherapeutic agents and radiation in inducing permanent alopecia of the scalp.
Eleven patients referred to our department over a period of 3 years for permanent alopecia after chemotherapy/radiotherapy or combination therapy were included. A detailed medical and therapeutic history was obtained from each patient and from medical records. Photography was done, and the scalp biopsies were taken. Patients were divided into three groups according to the type of therapy. The first group received conditioning chemotherapy prior to bone marrow transplantation. The second group had radiation for brain tumors, and the third group received both.
A comprehensive multicenter and multidisciplinary study is required to determine the definite causative agents, doses, and other cofactors that induce permanent alopecia following chemotherapy/radiotherapy, as well as the means to avoid this distressing outcome in surviving patients.
放化疗引起的脱发大多是暂时的。然而，也有报道称会发生永久性头皮脱发，尽管这种情况很少见。
本观察性病例系列研究的目的是确定引起头皮永久性脱发的化疗药物和放疗的种类和剂量。
在 3 年期间，共有 11 名患者因化疗/放疗或联合治疗后出现永久性脱发而被转诊至我们科室。从每位患者和病历中获得详细的医疗和治疗史。进行了摄影，并进行头皮活检。根据治疗类型将患者分为三组。第一组在骨髓移植前接受了预处理化疗。第二组接受了脑部肿瘤放疗，第三组同时接受了化疗和放疗。
需要进行全面的多中心和多学科研究，以确定化疗/放疗后引起永久性脱发的明确致病剂、剂量和其他因素，并找到避免幸存患者出现这种令人痛苦结局的方法。
