高血糖会增加超早产儿死亡的风险。
Hyperglycemia increases the risk of death in extremely preterm baboons.
机构信息
Department of Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
出版信息
Pediatr Res. 2013 Mar;73(3):337-43. doi: 10.1038/pr.2012.184. Epub 2012 Dec 7.
BACKGROUND
Transient neonatal hyperglycemia (HG) has been reported in up to 80% of extremely preterm human infants. We hypothesize that severe HG is associated with increased morbidity and mortality in preterm baboons.
METHODS
Sixty-six baboons born at 67% of gestation were studied. HG was defined as serum glucose level ≥150 mg/dl during the first week of life. Animals were stratified into two groups: severe HG (≥8 events) and nonsevere HG (<8 events).
RESULTS
HG developed in 65 of the 66 (98%) baboons that were included. A total of 3,386 glucose measurements were obtained. The mean serum glucose level was 159 ± 69 mg/dl for the severe HG group and 130 ± 48 mg/dl for the nonsevere HG group during the first week of life. No differences were found in gender, birth weight, sepsis, patent ductus arteriosus, or oxygenation/ventilation indexes between groups. Severe HG was associated with early death even after controlling for sepsis, postnatal steroid exposure, and catecholamine utilization.
CONCLUSION
HG is common in preterm baboons and is not associated with short-term morbidity. Severe HG occurring in the first week of life is associated with early death in preterm baboons.
背景
据报道，高达 80%的极早产儿会出现短暂性新生儿高血糖症（HG）。我们假设严重的 HG 与早产儿狨猴的发病率和死亡率增加有关。
方法
对 66 只在妊娠 67%时出生的狨猴进行了研究。HG 的定义为出生后第一周血清葡萄糖水平≥150mg/dl。动物分为两组：严重 HG（≥8 次）和非严重 HG（<8 次）。
结果
纳入的 66 只狨猴中有 65 只（98%）发生了 HG。共获得 3386 次血糖测量值。严重 HG 组在生命的第一周内的平均血清葡萄糖水平为 159±69mg/dl，非严重 HG 组为 130±48mg/dl。两组间的性别、出生体重、败血症、动脉导管未闭或氧合/通气指数无差异。即使在控制败血症、产后类固醇暴露和儿茶酚胺利用后，严重 HG 仍与早期死亡相关。
结论
HG 在早产狨猴中很常见，但与短期发病率无关。生命第一周内发生的严重 HG 与早产狨猴的早期死亡有关。
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