Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital NHS Trust, Cambridge, UK.
J Pediatr. 2010 Nov;157(5):715-9.e1-3. doi: 10.1016/j.jpeds.2010.04.032. Epub 2010 Jun 8.
To investigate the prevalence and determinants of hyperglycemia in the preterm population, as part of the Neonatal Insulin Therapy in Europe (NIRTURE) Trial.
We conducted prospective cohort analyses of continuous glucose monitoring data from control infants participating in an international randomized controlled trial. Data were collected from 188 very low birth weight infants (<1500 g).
In the first week of life, 80% of infants had evidence of glucose levels >8 mmol/L, and 32% had glucose levels >10 mmol/L >10% of the time. Independent risk factors for hyperglycemia included increasing prematurity, small size at birth, use of inotropes, lipid infusions, and sepsis. There was a lack of association between rate of dextrose infused and risk of hyperglycemia.
The prevalence of hyperglycemia in the very low birth weight infant is high, with marked variability in prevalence between infants, not simply related to rates of glucose infused, but to other potentially modifiable risk factors.
作为欧洲新生儿胰岛素治疗（NIRTURE）试验的一部分，调查早产儿人群中高血糖的患病率和决定因素。
我们对参与国际随机对照试验的对照婴儿的连续血糖监测数据进行了前瞻性队列分析。数据来自 188 名极低出生体重儿（<1500g）。
在生命的第一周，80%的婴儿有血糖水平>8mmol/L 的证据，32%的婴儿有血糖水平>10mmol/L>10%的时间。高血糖的独立危险因素包括早产增加、出生时体型小、使用正性肌力药、脂肪输注和败血症。葡萄糖输注率与高血糖风险之间缺乏关联。
极低出生体重儿高血糖的患病率很高，不同婴儿之间的患病率存在明显差异，与葡萄糖输注率无关，而与其他潜在可改变的危险因素有关。
