南非开始抗逆转录病毒治疗的 HIV 感染者中出现和未出现结核时的免疫恢复情况。
Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa.
机构信息
Centre for Infectious Disease Epidemiology and Research (CIDER), School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
出版信息
J Acquir Immune Defic Syndr. 2013 May 1;63(1):142-5. doi: 10.1097/QAI.0b013e318288b39d.
We studied the immune response after starting antiretroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/µL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.
我们研究了在南非的 3 个艾滋病治疗项目中，15646 名 HIV 感染者在开始抗逆转录病毒治疗（ART）时的免疫反应，其中一些患者在就诊时患有结核病（TB），另一些没有。与所有其他患者相比，就诊时患有结核病的患者的 CD4 细胞增加情况相似（每 6 个月调整差异为 4.9 个/µL，95%置信区间：0.2 至 9.7）。年龄较小、临床分期较晚、女性以及在开始 ART 时 CD4 细胞计数较低，均与 CD4 斜率更陡峭有关。在南非，就诊时患有结核病的 HIV 感染者在开始 ART 后会经历免疫恢复，其恢复情况并不比其他患者差。
Zotero 插件