5-苯并咪唑基-2'-脱氧尿苷 5-fdU 探针的合成及荧光光谱性质研究，该探针来源于邻苯二胺衍生物。
Synthesis and spectroscopic properties of fluorescent 5-benzimidazolyl-2'-deoxyuridines 5-fdU probes obtained from o-phenylenediamine derivatives.
机构信息
College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, State Key Laboratory of Virology, Wuhan University, Hubei, Wuhan, 430072, PR China.
出版信息
Org Biomol Chem. 2013 Feb 13;11(10):1610-3. doi: 10.1039/c3ob27519a.
PMID:23364618
Abstract
Fluorescent nucleosides (dU(bmz)) with desirable fluorescence quantum yield (Φ) are synthesized from almost non-fluorescent 5-fdU and o-phenylenediamine derivatives. The fluorescence of these nucleosides is quite sensitive to pH and organic solvents. 4-Methoxybenzene-1,2-diamine was used for the detection of 5-fdU among natural nucleosides.
摘要
合成了具有理想荧光量子产率（Φ）的荧光核苷（dU（bmz）），其原料为几乎无荧光的 5-fdU 和邻苯二胺衍生物。这些核苷的荧光对 pH 值和有机溶剂非常敏感。4-甲氧基苯-1,2-二胺用于检测天然核苷中的 5-fdU。
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