CKD-EPI 是评估系统性红斑狼疮患者肾功能最可靠的方程。
CKD-EPI is the most reliable equation to estimate renal function in patients with systemic lupus erythematosus.
机构信息
Regional Unit of Rheumatology and Osteoporosis, Hospital Central Dr. Ignacio Morones Prieto and Faculty of Medicine, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
出版信息
Nefrologia. 2013 Jan 18;33(1):99-106. doi: 10.3265/Nefrologia.pre2012.Jun.11101.
BACKGROUND
No study has determined the best equation for estimating renal function in patients with systemic lupus erythematosus (SLE), starting from a gold standard test.
OBJECTIVE
To evaluate the performance of cistatin/creatinine based equations for estimating renal function in patients with SLE.
METHODS
We conducted two phases: the first phase included 14 patients in which iothalamate clearance was used to determine the glomerular filtration rate (GFR) and compared with different equations based on cystatin C and/or creatinine. In the second phase, we used the best equation (a cystatin and creatinine-based equation) as "reference standard" to compare 5 creatinine-based equations in 55 patients with SLE.
RESULTS
In the first phase the equation developed by Stevens and colleagues (based on creatinine and cystatin C), was the best equation. In phase 2, the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation was the best equation with bias of -2. 1 ml/min/1.73, accuracy (P30) of 94.5% and precision (interquartile range of differences) of -2.1 ml/min/1.73.
CONCLUSIONS
Our data suggest that CKD-EPI is the best creatinine-based equation to estimate GFR in patients with SLE.
背景
尚无研究确定从金标准检测开始，估算系统性红斑狼疮（SLE）患者肾功能的最佳方程。
目的
评估胱抑素 C/肌酐方程估算 SLE 患者肾功能的性能。
方法
我们进行了两个阶段：第一阶段纳入了 14 例患者，使用碘酞酸盐清除率来确定肾小球滤过率（GFR），并与基于胱抑素 C 和/或肌酐的不同方程进行了比较。在第二阶段，我们使用最佳方程（基于胱抑素 C 和肌酐的方程）作为“参考标准”，在 55 例 SLE 患者中比较了 5 种基于肌酐的方程。
结果
在第一阶段，Stevens 及其同事开发的方程（基于肌酐和胱抑素 C）是最佳方程。在第二阶段，CKD-EPI（慢性肾脏病流行病学合作）方程是最佳方程，偏差为-2.1ml/min/1.73，准确度（P30）为 94.5%，精密度（四分位差）为-2.1ml/min/1.73。
结论
我们的数据表明，CKD-EPI 是估算 SLE 患者 GFR 的最佳基于肌酐的方程。
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