[The blood coagulation and fibrinolytic properties of the mucosa in the gastroduodenal area in patients with duodenal peptic ulcer].

A study was made of blood coagulating and fibrinolytic properties of different parts of the mucosa of the resected stomach and duodenum in 67 patients with duodenal ulcer. All the parts of the gastroduodenal zone manifested a dramatic increase of the total coagulation and thromboplastic activity, which was particularly marked in the ulcerous zone. High fibrinolytic activity in the gastric mucosa manifested itself only in initial dilutions. In the ulcerous zone of the duodenal mucosa, fibrinolytic activity was sharply reduced. High content of procoagulants and comparatively low potential of anticoagulants in the gastroduodenal mucosa point to activation of fibrin formation in these parts in patients suffering from duodenal ulcer. Impairment of local hemostasis may have pathogenetic importance in the development or course of ulcer disease.