Tabidze Z Sh
Ter Arkh. 1990;62(2):35-8.
A study was made of blood coagulating and fibrinolytic properties of different parts of the mucosa of the resected stomach and duodenum in 67 patients with duodenal ulcer. All the parts of the gastroduodenal zone manifested a dramatic increase of the total coagulation and thromboplastic activity, which was particularly marked in the ulcerous zone. High fibrinolytic activity in the gastric mucosa manifested itself only in initial dilutions. In the ulcerous zone of the duodenal mucosa, fibrinolytic activity was sharply reduced. High content of procoagulants and comparatively low potential of anticoagulants in the gastroduodenal mucosa point to activation of fibrin formation in these parts in patients suffering from duodenal ulcer. Impairment of local hemostasis may have pathogenetic importance in the development or course of ulcer disease.
对67例十二指肠溃疡患者切除的胃和十二指肠黏膜不同部位的血液凝固和纤维蛋白溶解特性进行了研究。胃十二指肠区域的所有部位均表现出总凝血和促凝血活性显著增加，这在溃疡区域尤为明显。胃黏膜中的高纤维蛋白溶解活性仅在初始稀释时表现出来。在十二指肠黏膜的溃疡区域，纤维蛋白溶解活性急剧降低。胃十二指肠黏膜中促凝血剂含量高而抗凝剂潜力相对较低，表明十二指肠溃疡患者这些部位的纤维蛋白形成被激活。局部止血功能受损可能在溃疡病的发生或发展过程中具有致病重要性。
