Barth Jens, Sünkel Michael, Bergner Katharina, Schickhuber Gerald, Winkler Jürgen, Klucken Jochen, Eskofier Björn
ASTRUM IT GmbH, Erlangen, Germany.
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:5122-5. doi: 10.1109/EMBC.2012.6347146.
Objective and rater independent analysis of movement impairment is one of the most challenging tasks in medical engineering. Especially assessment of motor symptoms defines the clinical diagnosis in Parkinson's disease (PD). A sensor-based system to measure the movement of the upper and lower extremities would therefore complement the clinical evaluation of PD. In this study two different sensor-based systems were combined to assess movement of 18 PD patients and 17 healthy controls. First, hand motor function was evaluated using a sensor pen with integrated accelerometers and pressure sensors, and second, gait function was assessed using a sports shoe with attached inertial sensors (gyroscopes,accelerometers).Subjects performed standardized tests for both extremities.Features were calculated from sensor signals to differentiate between patients and controls. For the latter, pattern recognition methods were used and the performance of four classifiers was compared. In a first step classification was done for every single system and in a second step for combined features of both systems. Combination of both motor task assessments substantially improved classification rates to 97%using the AdaBoost classifier for the experiment patients vs.controls.The combination of two different analysis systems led to enhanced, more stable, objective, and rater independent recognition of motor impairment. The method can be used as a complementary diagnostic tool for movement disorders.
对运动障碍进行客观且与评估者无关的分析是医学工程中最具挑战性的任务之一。尤其是运动症状的评估决定了帕金森病(PD)的临床诊断。因此,一种基于传感器的系统来测量上肢和下肢的运动,将补充帕金森病的临床评估。在本研究中,将两种不同的基于传感器的系统结合起来,以评估18名帕金森病患者和17名健康对照者的运动情况。首先,使用带有集成加速度计和压力传感器的传感笔评估手部运动功能,其次,使用附着有惯性传感器(陀螺仪、加速度计)的运动鞋评估步态功能。受试者对双下肢进行标准化测试。从传感器信号中计算特征以区分患者和对照者。对于后者,使用模式识别方法并比较了四种分类器的性能。第一步是对每个单独的系统进行分类,第二步是对两个系统的组合特征进行分类。使用AdaBoost分类器对实验中的患者与对照者进行分类时,两种运动任务评估的组合将分类率大幅提高到了97%。两种不同分析系统的结合导致对运动障碍的识别得到增强、更稳定、客观且与评估者无关。该方法可作为运动障碍的辅助诊断工具。