Speranskiĭ S D, Pogirnitskaia A V, Zorin V P, Cherenkevich S N, Speranskaia E Ch
Ukr Biokhim Zh (1978). 1990 Jan-Feb;62(1):104-8.
Ortho-benzoquinones have been studied for their effect on the processes of methemoglobin formation in the rabbit erythrocytes and reduction of potassium ferricyanide by the HeLa cells. It is established that the incubation of cells in the presence of lipophilic quinone OBQ-1 results in the formation of the intracellular methemoglobin in erythrocytes and the intensification of the ferricyanide reduction by HeLa cells. OBQ-2 differing in the presence of the polar sulphogroup does not react with the intracellular oxyhemoglobin and exerts no effect on the ferricyanide reduction. It is supposed that OBQ-1 may change the ratio of the oxidized and reduced metabolites in a cell, thus inducing in it a state of the oxidative stress. A conclusion is drawn hat ortho-benzoquinones are able to modify the redox properties of cells, the efficiency of modification depending on the chemical structure of the compounds.
邻苯醌对家兔红细胞高铁血红蛋白形成过程及HeLa细胞还原铁氰化钾的作用已得到研究。结果表明，在亲脂性醌OBQ-1存在下培养细胞，会导致红细胞内高铁血红蛋白的形成，并增强HeLa细胞对铁氰化钾的还原作用。含有极性磺酸基团的OBQ-2不与细胞内氧合血红蛋白发生反应，对铁氰化钾还原也无影响。推测OBQ-1可能改变细胞内氧化型和还原型代谢产物的比例，从而在细胞内诱导氧化应激状态。得出的结论是，邻苯醌能够改变细胞的氧化还原特性，其修饰效率取决于化合物的化学结构。
