Alex Raichel, Bhave Gauri, Al-Abed Mohammad A, Bashaboyina Aditya, Iyer Swathi, Watenpaugh Donald E, Zhang Rong, Behbehani Khosrow
Bioengineering Department, University of Texas at Arlington, Arlington, TX 76010, USA. raichelmary.alex@ mavs.uta.edu
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:5634-7. doi: 10.1109/EMBC.2012.6347272.
Obstructive Sleep Apnea (OSA) is a major sleep disorder with a prevalence of about 15 % among US adult population and can lead to cardiovascular diseases and stroke. In this study, we have investigated the OSA-induced concurrent rise in cerebral blood flow velocity and blood pressure in 5 positively diagnosed sleep apnea subjects. The subject population had a mean AHI of 57.94±25.73 and BMI of 33.66±7.27 kg/m(2). The results of this preliminary study yielded a relatively high correlation between rise in blood pressure and rise in cerebral blood flow velocity during apnea episodes (r=0.61±0.16) compared to normal breathing (r=0.28±0.26). These findings suggest that cerebral autoregulation may be less effective during apnea episodes.
阻塞性睡眠呼吸暂停（OSA）是一种主要的睡眠障碍，在美国成年人群中的患病率约为15%，可导致心血管疾病和中风。在本研究中，我们调查了5名确诊为睡眠呼吸暂停的受试者中，OSA引起的脑血流速度和血压同时升高的情况。受试者群体的平均呼吸暂停低通气指数（AHI）为57.94±25.73，体重指数（BMI）为33.66±7.27kg/m²。这项初步研究的结果显示，与正常呼吸（r=0.28±0.26）相比，呼吸暂停发作期间血压升高与脑血流速度升高之间的相关性相对较高（r=0.61±0.16）。这些发现表明，呼吸暂停发作期间脑自动调节可能不太有效。
