Saccomandi P, Schena E, Di Matteo F M, Pandolfi M, Martino M, Rea R, Panzera F, Silvestri S
Unit of Measurements and Biomedical Instrumentation, Center for Integrated Research, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo, Rome, Italy.
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:5687-90. doi: 10.1109/EMBC.2012.6347286.
The influence of some therapy-relevant parameters on Laser Induced Interstitial Thermotherapy (LITT) outcomes on pancreas is assessed. The aim is to execute a sensitivity analysis for an optimal treatment strategy on in vivo pancreas. A numerical model based on Bioheat Equation has been implemented to assess the influence of laser settings (power P and energy E), applicator radius (r(f)) and optical properties (effective attenuation coefficient, μ(eff)) on temperature (T) distribution. Effects on pancreas undergoing LITT have been evaluated with a twofold approach: 1) T rise and maximum T (T(max)) in tissue; 2) injured volumes (vaporized and coagulated ones). We consider parameters range in typical LITT values (P from 1.5 W to 6 W, E from 500 J to 1500 J, r(f) from 150 µm to 600 µm) and optical values reported in literature. Our analysis shows that, among others, P and μ(eff) are the principal influencing factors of thermal effects on pancreas undergoing LITT: P should be carefully chosen by operator to obtain the desired injured volumes, while the accurate measurement of tissue optical properties is crucial to carry out a safe and controlled thermal therapy on pancreas.
评估了一些与治疗相关的参数对胰腺激光诱导间质热疗（LITT）结果的影响。目的是对体内胰腺的最佳治疗策略进行敏感性分析。基于生物热方程的数值模型已被用于评估激光设置（功率P和能量E）、施源器半径（r(f)）和光学特性（有效衰减系数，μ(eff)）对温度（T）分布的影响。对接受LITT治疗的胰腺的影响已通过两种方法进行评估：1）组织中的温度升高和最高温度（T(max)）；2）损伤体积（汽化和凝固的体积）。我们考虑了典型LITT值范围内的参数（P从1.5 W到6 W，E从500 J到1500 J，r(f)从150 µm到600 µm）以及文献中报道的光学值。我们的分析表明，其中P和μ(eff)是对接受LITT治疗的胰腺热效应的主要影响因素：操作人员应谨慎选择P以获得所需的损伤体积，而准确测量组织光学特性对于在胰腺上进行安全且可控的热疗至关重要。
