经皮注射式胎儿起搏器：电极、机械设计与植入
Percutaneously injectable fetal pacemaker: electrodes, mechanical design and implantation.
作者信息
Zhou Li, Chmait Ramen, Bar-Cohen Yaniv, Peck Raymond A, Loeb Gerald E
机构信息
Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:6600-3. doi: 10.1109/EMBC.2012.6347507.
We are developing a self-contained cardiac pacemaker with a small, cylindrical shape (~3 × 20 mm) that permits it to be implanted percutaneously into a fetus to treat complete heart block and consequent hydrops fetalis, which is otherwise fatal. The device uses off-the-shelf components including a rechargeable lithium cell and a highly efficient relaxation oscillator encapsulated in epoxy and glass. A corkscrew electrode made from activated iridium can be screwed into the myocardium, followed by release of the pacemaker and a short, flexible lead entirely within the chest of the fetus to avoid dislodgement from fetal movement. The feasibility of implanting the device percutaneously under ultrasonic imaging guidance was demonstrated in acute adult rabbit experiments.
我们正在研发一种自成一体的心脏起搏器，其形状为小型圆柱形（约3×20毫米），这使其能够经皮植入胎儿体内，以治疗完全性心脏传导阻滞及随之而来的胎儿水肿，否则这将是致命的。该装置使用现成的组件，包括一个可充电锂电池和一个封装在环氧树脂和玻璃中的高效张弛振荡器。由活性铱制成的螺旋电极可拧入心肌，随后释放起搏器以及一根短的柔性导线，使其完全位于胎儿胸腔内，以避免因胎儿活动而移位。在成年兔急性实验中证明了在超声成像引导下经皮植入该装置的可行性。
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