经皮可注射式胎儿起搏器：电子设备、起搏阈值及功率预算
Percutaneously injectable fetal pacemaker: electronics, pacing thresholds, and power budget.
作者信息
Nicholson Adriana, Chmait Ramen, Bar-Cohen Yaniv, Zheng Kaihui, Loeb Gerald E
机构信息
Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089, USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:5730-3. doi: 10.1109/EMBC.2012.6347296.
We are developing a cardiac pacemaker that is designed to be implanted percutaneously into a fetus to treat complete heart block and consequent hydrops fetalis, which is otherwise fatal. One of the most significant considerations for this device is the technical challenges presented by the battery and charging system. The size of the device is limited to about 3 mm in diameter; batteries on this scale have very small charge capacities. The smaller capacity means that the device needs to be designed so that it uses as little current as possible and so that its battery can be recharged wirelessly. We determined the pacing thresholds for a simple relaxation oscillator that can be assembled from discrete, surface mount components and analyzed the power consumption of the device given different electrode configurations and stimulus parameters. An inductive recharging system will be required for some patients; it is feasible within the package constraints and under development.
我们正在研发一种心脏起搏器，其设计目的是经皮植入胎儿体内，以治疗完全性心脏传导阻滞及随之而来的胎儿水肿，否则这将是致命的。该设备最重要的考虑因素之一是电池和充电系统带来的技术挑战。设备尺寸限制在直径约3毫米；这种规模的电池充电容量非常小。容量较小意味着设备需要进行设计，使其尽可能少用电流，并使其电池能够无线充电。我们确定了一种简单张弛振荡器的起搏阈值，该振荡器可由分立的表面贴装元件组装而成，并分析了在不同电极配置和刺激参数下该设备的功耗。部分患者将需要感应充电系统；在封装限制范围内这是可行的，且正在研发中。
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