Xu Ke, Butlin Mark, Avolio Alberto P
Australian School of Advanced Medicine, Macquarie University, Sydney, NSW, Australia.
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:6661-4. doi: 10.1109/EMBC.2012.6347522.
Timing of biventricular pacing devices employed in cardiac resynchronization therapy (CRT) is a critical determinant of efficacy of the procedure. Optimization is done by maximizing function in terms of arterial pressure (BP) or cardiac output (CO). However, BP and CO are also determined by the hemodynamic load of the pulmonary and systemic vasculature. This study aims to use a lumped parameter circulatory model to assess the influence of the arterial load on the atrio-ventricular (AV) and inter-ventricular (VV) delay for optimal CRT performance.
心脏再同步治疗（CRT）中使用的双心室起搏装置的时机是该手术疗效的关键决定因素。优化是通过在动脉压（BP）或心输出量（CO）方面最大化功能来完成的。然而，BP和CO也由肺和体循环血管系统的血流动力学负荷决定。本研究旨在使用集总参数循环模型来评估动脉负荷对房室（AV）和心室间（VV）延迟的影响，以实现最佳CRT性能。
