Chappuis S, Ribi C, Spertini F
Service d'immunologie et allergie, CHUV, 1011 Lausanne.
Rev Med Suisse. 2013 Jan 9;9(368):12-6.
TNFalpha blocking agents are effective and essential tools in the management of many inflammatory conditions including rheumatoid arthritis, spondylarthropathies and chronic inflammatory bowel disease. With time, some known side-effects have gained in importance and others have appeared. This article focuses on the potential risks of infection and autoimmunity induced by TNFalpha blocking agents and on the strategy to prevent and treat such adverse events.
肿瘤坏死因子α阻断剂是治疗多种炎症性疾病（包括类风湿性关节炎、脊柱关节病和慢性炎症性肠病）的有效且重要的工具。随着时间的推移，一些已知的副作用变得更加突出，另一些则出现了。本文重点关注肿瘤坏死因子α阻断剂引起的感染和自身免疫的潜在风险，以及预防和治疗此类不良事件的策略。
