Pediatric Pulmonary Unit, Shaare Zedek Medical Center, The Hebrew University, School of Medicine, Jerusalem, Israel.
Acta Paediatr. 2013 May;102(5):510-3. doi: 10.1111/apa.12178. Epub 2013 Feb 13.
To evaluate in a prospective, cross-sectional cohort study the impact of inhaled corticosteroids (ICS) on bone speed of sound (SOS) in asthmatic children.
Children with mild-to-moderate asthma from a pulmonary clinic were assessed over a 2-month period. We recorded clinical and demographic data related to asthma severity, its treatment, participation in sports and dairy intake. Tibial SOS was measured using the Sunlight Omnisense 7000S quantitative ultrasound bone sonometer.
Eighty-five mild-to-moderate asthmatic children were studied. Age range was 1.4-17 years (71.7% boys). Average disease duration was approximately 5 years, and the average cumulative duration of ICS therapy was approximately 1.5 years. Average SOS Z-score was slightly negative and varied between -3.5 and +1.9 SD. In univariate analysis, SOS Z-score was negatively correlated with asthma duration (R(2) = 5.7%, p = 0.028) and ICS duration (R(2) = 4.9%, p = 0.042). In backward stepwise multiple regression, where SOS Z-score was the dependent variable, the only variables that remained significant in the final analysis were gender (p = 0.015), asthma duration (p = 0.003) and BMI (p = 0.048) (R(2) for the model 17.52% p = 0.01).
Prolonged inhaled steroid therapy appears to have no deleterious effect upon SOS in children with mild-to-moderate persistent asthma.
在一项前瞻性、横断面队列研究中评估吸入皮质类固醇（ICS）对哮喘儿童骨声速（SOS）的影响。
从呼吸科门诊招募轻度至中度哮喘儿童进行评估。我们记录了与哮喘严重程度、治疗、参与运动和乳制品摄入相关的临床和人口统计学数据。使用 Sunlight Omnisense 7000S 定量超声骨声速仪测量胫骨 SOS。
研究了 85 名轻度至中度哮喘儿童。年龄范围为 1.4-17 岁（71.7%为男孩）。平均疾病持续时间约为 5 年，平均累积 ICS 治疗时间约为 1.5 年。平均 SOS Z 分数略为负值，范围在-3.5 到+1.9 SD 之间。在单因素分析中，SOS Z 分数与哮喘持续时间（R(2) = 5.7%，p = 0.028）和 ICS 持续时间（R(2) = 4.9%，p = 0.042）呈负相关。在向后逐步多元回归中，将 SOS Z 分数作为因变量，在最终分析中仍然具有统计学意义的变量只有性别（p = 0.015）、哮喘持续时间（p = 0.003）和 BMI（p = 0.048）（模型的 R(2)为 17.52%，p = 0.01）。
在轻度至中度持续性哮喘儿童中，长期吸入皮质类固醇治疗似乎对 SOS 没有不良影响。
