Teixeira C, Gomes R
Fundação Oswaldo Cruz (FIOCRUZ), Centro de Pesquisas Gonçalo Moniz, Salvador, BA, Brasil.
Braz J Med Biol Res. 2013 Feb;46(2):109-16. doi: 10.1590/1414-431x20122460. Epub 2013 Feb 1.
Animal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the elaborate details of the immune response that follows infection. Different models have been extensively used to investigate putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. The greatest challenge has been the improvement and adaptation of these models to reflect the reality of human disease and the screening of vaccine candidates capable of overcoming the challenge of natural transmission. This review will discuss the advantages and challenges of using experimental animal models for vaccine development and how the knowledge achieved can be extrapolated to human disease by looking into two important parasitic diseases: malaria and leishmaniasis.
动物模型作为有用的工具已有很长历史，不仅用于测试和筛选疫苗，还有助于了解感染后免疫反应的详细情况。不同的模型已被广泛用于研究针对寄生虫病的假定免疫保护关联因素，这对于成功研发疫苗至关重要。最大的挑战在于改进和调整这些模型以反映人类疾病的实际情况，以及筛选能够克服自然传播挑战的候选疫苗。本综述将通过研究两种重要的寄生虫病：疟疾和利什曼病，来讨论使用实验动物模型进行疫苗研发的优势和挑战，以及所获得的知识如何外推至人类疾病。
