Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Nat Immunol. 2014 May;15(5):403-5. doi: 10.1038/ni.2853.
Live and live-attenuated whole organism vaccines against malaria and cutaneous leishmaniasis due to remain the most uniformly effective vaccines against human parasitic diseases. These vaccines are discussed in terms of the nature of the T cell populations that mediate the strong and durable localized immunity to these infections, and the requirement for persisting antigen to generate and maintain the protective response. The difficulties in developing subunit vaccines that fulfill this requirement argue that despite their own formidable problems in manufacture and delivery, live and live- attenuated whole organism vaccines against human parasitic diseases should be vigorously pursued.
针对疟疾和皮肤利什曼病的活疫苗和减毒活疫苗仍然是针对人体寄生虫病最有效、最普遍的疫苗。本文将讨论介导针对这些感染的强烈和持久局部免疫的 T 细胞群体的性质，以及产生和维持保护反应所需的持续抗原。开发符合这一要求的亚单位疫苗存在困难，这表明，尽管活疫苗和减毒活疫苗在制造和使用方面存在自身的巨大问题，但仍应大力研究针对人体寄生虫病的活疫苗和减毒活疫苗。
