Chemistry Division, Bhabha Atomic Research Centre, Mumbai-400 085, India.
Dalton Trans. 2013 Apr 14;42(14):4885-96. doi: 10.1039/c2dt32508j.
Magnetic nanoparticles based hyperthermia therapy is a possible low cost and effective technique for killing cancer tissues in the human body. Fe3O4 and Fe3O4@YPO4:5Eu hybrid magnetic nanoparticles are prepared by co-precipitation method and their average particle sizes are found to be ∼10 and 25 nm, respectively. The particles are spherical, non-agglomerated and highly dispersible in water. The crystallinity of as-prepared YPO4:5Eu sample is more than Fe3O4@YPO4:5Eu hybrid magnetic nanoparticles. The chemical bonds interaction between Fe3O4 and YPO4:5Eu is confirmed through FeO-P. The magnetization of hybrid nanocomposite shows magnetization Ms = 11.1 emu g(-1) with zero coercivity (measured at 2 × 10(-4) Oe) at room temperature indicating superparamagnetic behaviour. They attain hyperthermia temperature (~42 °C) under AC magnetic field showing characteristic induction heating of the prepared nanohybrid and they will be potential material for biological application. Samples produce the red emission peaks at 618 nm and 695 nm, which are in range of biological window. The quantum yield of YPO4:5Eu sample is found to be 12%. Eu(3+) present on surface and core could be distinguished from luminescence decay study. Very high specific absorption rate up to 100 W g(-1) could be achieved. The intracellular uptake of nanocomposites is found in mouse fibrosarcoma (Wehi 164) tumor cells by Prussian blue staining.
基于磁性纳米粒子的热疗是一种可能的低成本、有效治疗人体癌组织的技术。采用共沉淀法制备了 Fe3O4 和 Fe3O4@YPO4:5Eu 杂化磁性纳米粒子，其平均粒径分别约为 10nm 和 25nm。这些粒子呈球形，不团聚，在水中高度分散。所制备的 YPO4:5Eu 样品的结晶度高于 Fe3O4@YPO4:5Eu 杂化磁性纳米粒子。通过 FeO-P 证实了 Fe3O4 和 YPO4:5Eu 之间的化学键相互作用。杂化纳米复合材料的磁化率在室温下具有零矫顽力（在 2×10(-4) Oe 下测量）为 11.1 emu g(-1)，表明具有超顺磁性。它们在交流磁场下达到热疗温度（~42°C），表现出所制备纳米杂化物的特征感应加热，并且它们将成为潜在的生物应用材料。样品在 618nm 和 695nm 处产生红色发射峰，处于生物窗口范围内。YPO4:5Eu 样品的量子产率为 12%。可以通过荧光衰减研究从表面和核区分 Eu(3+)。可以实现高达 100 W g(-1)的超高比吸收率。通过普鲁士蓝染色发现纳米复合材料在小鼠纤维肉瘤（Wehi 164）肿瘤细胞中的细胞内摄取。
