Department of Chemistry , Manipur University , Imphal 795003 Manipur , India.
Chemistry Division , Bhabha Atomic Research Centre , Mumbai 400085 Maharashtra , India.
J Phys Chem B. 2018 Jul 12;122(27):6862-6871. doi: 10.1021/acs.jpcb.8b02364. Epub 2018 Jun 29.
Not many reports are available on magnetic-luminescent nanocomposites for cancer hyperthermia applications. Further, such nanocomposites on Mn-doped iron oxide may be available rather rarely. Studies on the induction heating properties within the threshold magnetic field and frequency factors are still rare. In most cases, magnetic nanoparticles are studied for hyperthermia and lanthanide-doped luminescent nanoparticles for certain biomedical applications. Here, we report on water-dispersible superparamagnetic manganese-doped iron oxide (MnFeO) nanoparticles and a polyethylene glycol6000-coated magnetic-luminescent nanocomposite. The nanocomposite is composed of magnetic MnFeO (average size 10-20 nm) nanoparticles and red-emitting YVO:Eu (average size 40-50 nm) nanoparticles. These magnetic nanoparticles and nanocomposites are studied for their induction heating abilities at different acceptable Hf values ( H, strength of alternating magnetic field and f, the operating frequency). The operational Hf values lie in the ranges of 2.15 × 10 to 4.58 × 10 kA m s that are well below the threshold limit of 5 × 10 kA m s. A specific absorption rate as high as 132 and 63 W/g, respectively, for MnFeO and MnFeO@YVO:Eu, can be achieved. The rate of heating and the temperature achieved with time can be tuned with concentrations as well as magnetic constituents in the nanocomposites. Hemocompatibility analysis revealed high blood compatibility with <5% hemolysis. The cytotoxicity analysis in the MCF-7 cell line showed that the cell viability is 74-85% for 0.2-0.5 mg of the magnetic-luminescent nanocomposites. Beyond this concentration, the percentage of cell death is very high. The red-emitting magnetic-luminescent nanocomposites will be useful for in vitro optical imaging and tracking of magnetic nanoparticles. The magnetization analysis showed that the samples have high enough saturation magnetization and low residual magnetization, which is quite suitable for clinical applications. The water dispersibility, hemocompatibility, and cytotoxicity assay in conjunction with their efficient induction heating abilities have shown that these magnetic-luminescent nanocomposites will have potential applications in magnetic fluid hyperthermia and optical imaging.
用于癌症热疗的磁性发光纳米复合材料的报道并不多。此外，掺杂锰的氧化铁纳米复合材料可能很少见。在阈值磁场和频率因子范围内的感应加热特性的研究仍然很少。在大多数情况下，磁性纳米粒子用于热疗，镧系掺杂发光纳米粒子用于某些生物医学应用。在这里，我们报告了水可分散的超顺磁性锰掺杂氧化铁（MnFeO）纳米粒子和聚乙二醇 6000 包覆的磁性发光纳米复合材料。该纳米复合材料由磁性 MnFeO（平均尺寸 10-20nm）纳米粒子和红色发射的 YVO：Eu（平均尺寸 40-50nm）纳米粒子组成。研究了这些磁性纳米粒子和纳米复合材料在不同可接受的 Hf 值（H，交变磁场的强度和 f，工作频率）下的感应加热能力。工作 Hf 值位于 2.15×10 到 4.58×10 kA m s 的范围内，远低于 5×10 kA m s 的阈值极限。MnFeO 和 MnFeO@YVO：Eu 分别可以达到高达 132 和 63 W/g 的比吸收率。可以通过浓度以及纳米复合材料中的磁性成分来调整加热速率和随时间达到的温度。血液相容性分析显示溶血率<5%，血液相容性高。在 MCF-7 细胞系中的细胞毒性分析表明，对于 0.2-0.5mg 的磁性发光纳米复合材料，细胞存活率为 74-85%。超过这个浓度，细胞死亡率非常高。红色发射的磁性发光纳米复合材料将可用于体外光学成像和磁性纳米粒子的跟踪。磁化分析表明，这些样品具有足够高的饱和磁化强度和低剩余磁化强度，非常适合临床应用。水分散性、血液相容性和细胞毒性测定以及它们的高效感应加热能力表明，这些磁性发光纳米复合材料将在磁性流体热疗和光学成像中有潜在的应用。
