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The neglected cousin of the hepatocyte: how gallbladder epithelial cells might contribute to cholesterol gallstone formation.

作者信息

Dikkers Arne, Tietge Uwe J F

出版信息

Dig Dis Sci. 2013 Feb;58(2):296-8. doi: 10.1007/s10620-012-2541-5. Epub 2013 Jan 31.

DOI:10.1007/s10620-012-2541-5
PMID:23371007
Abstract
摘要

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The neglected cousin of the hepatocyte: how gallbladder epithelial cells might contribute to cholesterol gallstone formation.肝细胞被忽视的“表亲”：胆囊上皮细胞如何可能促成胆固醇胆结石的形成。
Dig Dis Sci. 2013 Feb;58(2):296-8. doi: 10.1007/s10620-012-2541-5. Epub 2013 Jan 31.
2
ATP-binding cassette sterol transporters are differentially expressed in normal and diseased human gallbladder.三磷酸腺苷结合盒固醇转运蛋白在正常和病变人胆囊中差异表达。
Dig Dis Sci. 2013 Feb;58(2):431-9. doi: 10.1007/s10620-012-2481-0. Epub 2012 Nov 22.
3
ABCG5 and ABCG8 are expressed in gallbladder epithelial cells.ABCG5和ABCG8在胆囊上皮细胞中表达。
Biochem Biophys Res Commun. 2003 Aug 8;307(4):1021-8. doi: 10.1016/s0006-291x(03)01296-8.
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Abcc6 deficiency in mice leads to altered ABC transporter gene expression in metabolic active tissues.Abcc6 基因缺陷的小鼠在代谢活跃组织中导致 ABC 转运蛋白基因表达改变。
Lipids Health Dis. 2019 Jan 5;18(1):2. doi: 10.1186/s12944-018-0943-x.
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Specific gene expression of ATP-binding cassette transporters and nuclear hormone receptors in rat liver parenchymal, endothelial, and Kupffer cells.大鼠肝脏实质细胞、内皮细胞和库普弗细胞中ATP结合盒转运蛋白和核激素受体的特异性基因表达。
J Biol Chem. 2003 Jul 11;278(28):25448-53. doi: 10.1074/jbc.M301189200. Epub 2003 Apr 18.
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Cholesterol and plant sterol efflux from cultured intestinal epithelial cells is mediated by ATP-binding cassette transporters.胆固醇和植物甾醇从培养的肠上皮细胞流出是由ATP结合盒转运蛋白介导的。
Biosci Biotechnol Biochem. 2007 Aug;71(8):1886-95. doi: 10.1271/bbb.70109. Epub 2007 Aug 7.
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Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice.过氧化物酶体增殖物激活受体α（PPARα）介导的小鼠多药耐药蛋白2（Mdr2）表达及功能调控
Biochem J. 2003 Feb 1;369(Pt 3):539-47. doi: 10.1042/BJ20020981.
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Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones.依折麦布对胆固醇性胆结石预防及溶解的作用
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Br J Nutr. 2006 Mar;95(3):618-22. doi: 10.1079/bjn20051659.

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Effect of nicotine on cholesterol gallstone formation in C57BL/6J mice fed on a lithogenic diet.尼古丁对喂食致石性饮食的C57BL/6J小鼠胆固醇胆结石形成的影响。
Exp Ther Med. 2023 Jan 3;25(2):84. doi: 10.3892/etm.2023.11783. eCollection 2023 Feb.
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A computer study of the risk of cholesterol gallstone associated with obesity and normal weight.计算机研究肥胖和正常体重与胆固醇胆石症风险的关系。
Sci Rep. 2021 Apr 23;11(1):8868. doi: 10.1038/s41598-021-88249-w.
3
Cholesterol gallstone disease: focusing on the role of gallbladder.胆固醇胆囊结石病：聚焦于胆囊的作用。

本文引用的文献

1
ATP-binding cassette sterol transporters are differentially expressed in normal and diseased human gallbladder.三磷酸腺苷结合盒固醇转运蛋白在正常和病变人胆囊中差异表达。
Dig Dis Sci. 2013 Feb;58(2):431-9. doi: 10.1007/s10620-012-2481-0. Epub 2012 Nov 22.
2
Molecular mechanisms responsible for the reduced expression of cholesterol transporters from macrophages by low-dose endotoxin.低剂量内毒素导致巨噬细胞胆固醇转运蛋白表达减少的分子机制。
Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):24-33. doi: 10.1161/ATVBAHA.112.300049. Epub 2012 Nov 1.
3
Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus.
Lab Invest. 2015 Feb;95(2):124-31. doi: 10.1038/labinvest.2014.140. Epub 2014 Dec 15.
胆固醇结石病致病变异的基因和功能鉴定：ABCG5/8 结石形成基因座。
Hepatology. 2013 Jun;57(6):2407-17. doi: 10.1002/hep.26009. Epub 2013 Jan 25.
4
Therapy of gallstone disease: What it was, what it is, what it will be.胆结石疾病的治疗：过去如何，现在如何，未来又将如何。
World J Gastrointest Pharmacol Ther. 2012 Apr 6;3(2):7-20. doi: 10.4292/wjgpt.v3.i2.7.
5
Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease.胆汁酸受体作为治疗血脂异常和心血管疾病的靶点。
J Lipid Res. 2012 Sep;53(9):1723-37. doi: 10.1194/jlr.R024794. Epub 2012 May 1.
6
Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies.胆固醇逆向转运调控的研究进展——对现有动物研究的全面评估
Nutr Metab (Lond). 2012 Mar 29;9(1):25. doi: 10.1186/1743-7075-9-25.
7
Hepatic Niemann-Pick C1-like 1.肝尼曼-皮克 C1 样 1 型。
Curr Opin Lipidol. 2011 Jun;22(3):225-30. doi: 10.1097/MOL.0b013e3283468c28.
8
Biliary cholesterol secretion: more than a simple ABC.胆汁胆固醇分泌：不止是简单的 ABC。
World J Gastroenterol. 2010 Dec 21;16(47):5936-45. doi: 10.3748/wjg.v16.i47.5936.
9
Biliary sterol secretion is required for functional in vivo reverse cholesterol transport in mice.胆汁固醇分泌是小鼠体内功能性胆固醇逆向转运所必需的。
Gastroenterology. 2011 Mar;140(3):1043-51. doi: 10.1053/j.gastro.2010.11.055. Epub 2010 Dec 4.
10
Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation.靶向删除Gpbar1可保护小鼠免受胆固醇胆结石形成。
Biochem J. 2006 Sep 15;398(3):423-30. doi: 10.1042/BJ20060537.