Department of Pathology, Federal University of São Paulo-UNIFESP, Sao Paulo, Brazil.
Sleep Breath. 2013 Sep;17(3):905-10. doi: 10.1007/s11325-012-0797-9. Epub 2013 Feb 1.
Sleep disorders are associated with various human pathologies and interfere with biological processes essential for health and quality of life. On the other hand, cancer is one of the most common diseases worldwide with an average of 1,500 deaths per day in the USA. Is there a factor common to both sleep disorders and cancer that serves to link these conditions?
It is a normal process for cellular metabolism to produce reactive oxidant series (ROS). However, when the production of ROS overcomes the antioxidant capacity of the cell to eliminate these products, the resulting state is called oxidative stress. Oxidative DNA damage may participate in ROS-induced carcinogenesis. Moreover, ROS are also produced in the sleep deprivation process. The aim of this article is to review pathways and mechanisms that may point to oxidative stress as a link between sleep deprivation and cancer.
睡眠障碍与各种人类病理有关，并干扰对健康和生活质量至关重要的生物过程。另一方面，癌症是世界上最常见的疾病之一，仅在美国，每天就有平均 1500 人死亡。在睡眠障碍和癌症这两种病症之间是否存在一种共同的因素，可以将它们联系起来？
细胞代谢产生活性氧化自由基系列（ROS）是正常的。然而，当 ROS 的产生超过细胞消除这些产物的抗氧化能力时，由此产生的状态称为氧化应激。氧化 DNA 损伤可能参与 ROS 诱导的致癌作用。此外，ROS 也在睡眠剥夺过程中产生。本文的目的是综述可能表明氧化应激是睡眠剥夺和癌症之间联系的途径和机制。
