Komorowski R A
Department of Pathology, Medical College of Wisconsin, Milwaukee.
Am J Surg Pathol. 1990 Jun;14(6):548-54. doi: 10.1097/00000478-199006000-00005.
Biopsy specimens taken from six patients with diversion colitis, an inflammatory process that occurs in the bypassed colonic segment after diversion of the fecal stream, showed a spectrum of histologic changes ranging from mild colitis to those seen in severe active chronic ulcerative colitis. Histologic abnormalities included aphthous ulcers, crypt distortion, atrophy and abscesses, a villous colonic surface, and a mixed acute and chronic inflammatory infiltrate with patchy lymphoid hyperplasia. Accurate pathologic diagnosis is dependent on clinical history, comparison of histologic morphology in both colonic segments, and response to therapy with local application of short chain fatty acids.
取自六例改道性结肠炎患者的活检标本显示出一系列组织学变化，改道性结肠炎是一种在粪便流改道后发生于旷置结肠段的炎症过程，变化范围从轻度结肠炎到重度活动性慢性溃疡性结肠炎所见的变化。组织学异常包括阿弗他溃疡、隐窝变形、萎缩和脓肿、结肠绒毛表面以及伴有散在性淋巴样增生的混合性急慢性炎性浸润。准确的病理诊断取决于临床病史、两个结肠段组织形态学的比较以及局部应用短链脂肪酸的治疗反应。
