Karaosmanoglu Hayat Kumbasar, Aydin Ozlem Altuntas, Nazlican Ozcan
Infectious Diseases and Clinical Microbiology, Haseki Training and Research Hospital, Istanbul, Turkey.
HIV Clin Trials. 2013 Jan-Feb;14(1):17-20. doi: 10.1310/hct1401-17.
Isolated antibody to hepatitis B core antigen (anti-HBc) is frequent in HIV-infected patients, and it may be a marker of occult hepatitis B. We aimed to determine the prevalence and associated risk factors of isolated anti-HBc among HIV-infected patients in Turkey, which is classified as an intermediate HBV, low HIV endemic region.
HIV/AIDS patients followed by the Infectious Diseases and Clinical Microbiology Outpatient Clinic of Haseki Training and Research Hospital between January 2006 and March 2011 were included in this study. Medical records were reviewed to determine the prevalence of isolated anti-HBc and to identify the risk factors associated with isolated anti-HBc. The frequency of isolated anti-HBc in 209 HIV-infected patients was compared with 83 volunteer blood donors.
Of 209 HIV-infected patients, 40 subjects (19.1%) had isolated anti-HBc compared with control group, which consisted of 83 volunteer blood donors who had similar age (P = .13) and sex (P = .29). In the control group, only 2 (2.4%) had isolated anti-HBc. Isolated anti-HBc was significantly more frequent in HIV-infected patients (P < .001). The characteristics such as age, gender, injecting drug use, anti-HCV seropositivity, and CD4 cell counts were not significantly different between HIV-infected patients with or without isolated anti-HBc. Only 3 (7.5%) of HIV-infected patients had occult infection.
Prevalence of isolated anti-HBc in Turkish HIV-infected patients was 19.1%, which was significantly more frequent than in blood donors. Isolated anti-HBc could be associated with occult infection. Thus, all HIV-infected patients should be screened for anti-HBc before starting antiretroviral therapy.
在HIV感染患者中，单独的乙肝核心抗原抗体（抗-HBc）很常见，它可能是隐匿性乙型肝炎的一个标志物。我们旨在确定在土耳其（被归类为乙型肝炎中度流行、艾滋病低度流行地区）的HIV感染患者中单独抗-HBc的患病率及相关危险因素。
纳入2006年1月至2011年3月期间在哈塞基培训与研究医院传染病及临床微生物门诊随访的HIV/AIDS患者。回顾病历以确定单独抗-HBc的患病率，并识别与单独抗-HBc相关的危险因素。将209例HIV感染患者中单独抗-HBc的频率与83名自愿献血者进行比较。
在209例HIV感染患者中，40例（19.1%）有单独抗-HBc，与之相比，对照组由83名年龄（P = 0.13）和性别（P = 0.29）相似的自愿献血者组成。在对照组中，只有2例（2.4%）有单独抗-HBc。HIV感染患者中单独抗-HBc明显更常见（P < 0.001）。有或没有单独抗-HBc的HIV感染患者在年龄、性别、注射吸毒、抗-HCV血清阳性及CD4细胞计数等特征方面无显著差异。HIV感染患者中只有3例（7.5%）有隐匿感染。
土耳其HIV感染患者中单独抗-HBc的患病率为19.1%，明显高于献血者。单独抗-HBc可能与隐匿感染有关。因此，所有HIV感染患者在开始抗逆转录病毒治疗前都应筛查抗-HBc。
