Popescu Irinel, Alexandrescu Sorin Tiberiu
Dan Setlacec Center of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania.
Acta Chir Iugosl. 2012;59(2):47-55. doi: 10.2298/aci1202047p.
Approximately 25% of patients with colorectal cancer present synchronous metastases, most frequently located in the liver.
The assessment of optimal therapeutic strategies for the primary tumor in such patients.
We analyzed the outcomes of 209 patients who underwent simultaneous or delayed resection of the primary tumor and liver metastases, the survival rates of patients with initially unresectable liver metastases that were rendered resectable, and the prognostic factors related to the primary tumor.
The outcomes of simultaneous resections were similar to those of delayed resection. In patients with initially unresectable liver metastases that were rendered resectable, the survival rates were similar to those of patients with initially resectable metastases. The survival rate of N2 patients was significantly lower than those of N1 and N0 patients.
Simultaneous resection provides a safety profile and survival rate similar to that of delayed resection. The N category allows for prognostic estimation in metastatic colorectal patients.
约25%的结直肠癌患者存在同时性转移，最常见于肝脏。
评估此类患者原发性肿瘤的最佳治疗策略。
我们分析了209例行原发性肿瘤和肝转移瘤同期或延期切除患者的治疗结果、初始不可切除的肝转移瘤经治疗后变为可切除患者的生存率，以及与原发性肿瘤相关的预后因素。
同期切除的结果与延期切除相似。初始不可切除的肝转移瘤经治疗后变为可切除的患者，其生存率与初始可切除转移瘤的患者相似。N2期患者的生存率显著低于N1期和N0期患者。
同期切除与延期切除具有相似的安全性和生存率。N分期可用于评估转移性结直肠癌患者的预后。
