通过碱促进的均裂芳香取代（BHAS）进行交叉脱氢偶联：芴酮和呫吨酮的合成。
Cross dehydrogenative coupling via base-promoted homolytic aromatic substitution (BHAS): synthesis of fluorenones and xanthones.
机构信息
Fachbereich Chemie, Organisch-Chemisches Institut, Westfälische Wilhelms-Universität, Corrensstrasse 40, 48149 Münster, Germany.
出版信息
Org Lett. 2013 Feb 15;15(4):928-31. doi: 10.1021/ol4000857. Epub 2013 Feb 1.
Cross dehydrogenative coupling reactions occurring via base-promoted homolytic aromatic substitutions (BHASs) are reported. Fluorenones and xanthones are readily prepared via CDC starting with readily available ortho-formyl biphenyls and ortho-formyl biphenylethers, respectively. The commercially available and cheap tBuOOH is used as an oxidant. Initiation of the radical chain reaction is best achieved with small amounts of FeCp(2) (0.1 or 1 mol %).
通过碱促进的均裂芳香取代（BHAS）发生的交叉脱氢偶联反应被报道。从易得的邻甲酰基联苯和邻甲酰基联苯醚出发，分别通过 CDC 容易制备芴酮和呫吨酮。商业可得且廉价的 tBuOOH 用作氧化剂。少量 FeCp(2)（0.1 或 1 mol %）最有利于引发自由基链反应。
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