通过碱促进的分子内芳香取代反应，苯肼作为直接芳基 C-H 芳基化的引发剂。
Phenyl hydrazine as initiator for direct arene C-H arylation via base promoted homolytic aromatic substitution.
机构信息
Organisch-Chemisches Institut, NRW Graduate School of Chemistry, Westfälische Wilhelms-Universität , Corrensstrasse 40, 48149 Münster, Germany, and Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
出版信息
Org Lett. 2013 Dec 6;15(23):6102-5. doi: 10.1021/ol402995e. Epub 2013 Nov 19.
Abstract
A simple and efficient direct radical arylation of unactivated arenes is described which uses cheap and commercially available phenyl hydrazine as an initiator. The reaction occurs through a base promoted homolytic aromatic substitution (BHAS) mechanism involving aryl radicals and aryl radical anions as intermediates and offers a practical approach for preparation of an array of substituted biaryls.
摘要
本文描述了一种简单高效的未活化芳基的直接自由基芳基化反应，该反应以廉价且市售的苯肼作为引发剂。该反应通过碱促进的均裂芳香取代（BHAS）机理进行，涉及芳基自由基和芳基自由基阴离子作为中间体，为制备一系列取代联芳烃提供了一种实用的方法。
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