具有高治疗潜力的N-吡咯芳基砜。

N-Pyrrylarylsulfones with High Therapeutic Potential.

作者信息

Famiglini Valeria, Castellano Sabrina, Silvestri Romano

机构信息

Department of Drug Chemistry and Technologies, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, I-00185 Roma, Italy.

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, I-84084 Fiscano, Salerno, Italy.

出版信息

Molecules. 2017 Mar 9;22(3):434. doi: 10.3390/molecules22030434.

This review illustrates the various studies made to investigate the activity of -pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure-activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential of -pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new -pyrrylarylsulfone based agents.