Mrówka-Kata Katarzyna, Kata Dariusz, Kyrcz-Krzemień Sławomira, Sowa Paweł
Katedra i Oddział Kliniczny Laryngologii w Zabrzu Śląskiego Uniwersytetu Medycznego w Katowicach, ul. M. Skłodowskiej-Curie 10, 41-800 Zabrze, Poland.
Otolaryngol Pol. 2013 Jan-Feb;67(1):1-5. doi: 10.1016/j.otpol.2012.05.001. Epub 2012 May 4.
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a benign and self-limited disease, characterized typically by enlargement of regional lymph nodes accompanied by fever. KFD affects predominantly young adult females of Asian origin and is rarely seen in European countries, where it may cause diagnostic difficulties. Two cases of KFD in a 33 and 27-year-old woman with mild fever, malaise, lymphadenopathy initially misdiagnosed for indolent non-Hodgkin's lymphoma was presented. The definitive diagnosis was established on the basis of histopathological examination of totally excised cervical lymph nodes. The propriety diagnosis allowed us to avoid inappropriate chemotherapy. The disease course in our patient was uneventful during the 1.5 and 12-year follow-up period. The clinical presentations, complications as well as current concepts on pathogenesis, diagnosis and treatment of the Kikuchi-Fujimoto disease was briefly reviewed in this paper. The need of a long-term follow-up of patients with Kikuchi-Fujimoto disease was emphasized.
菊池-藤本病（KFD），又称组织细胞坏死性淋巴结炎，是一种良性自限性疾病，其典型特征为局部淋巴结肿大并伴有发热。KFD主要影响亚洲裔年轻成年女性，在欧洲国家很少见，在那里可能会导致诊断困难。本文介绍了两例分别为33岁和27岁女性的KFD病例，她们最初因低热、不适、淋巴结病被误诊为惰性非霍奇金淋巴瘤。最终诊断是基于完全切除的颈部淋巴结的组织病理学检查确定的。正确的诊断使我们避免了不适当的化疗。在1.5年和12年的随访期内，我们患者的病程平稳。本文简要回顾了菊池-藤本病的临床表现、并发症以及目前关于其发病机制、诊断和治疗的概念。强调了对菊池-藤本病患者进行长期随访的必要性。
