Laboratoire des Produits Naturels d'Origine Végétale et de Synthèse Organique, Université Mentouri-Constantine, Constantine 25000, Algeria.
Bioorg Med Chem Lett. 2013 Mar 1;23(5):1274-8. doi: 10.1016/j.bmcl.2013.01.004. Epub 2013 Jan 11.
Several new highly functionalized imidazolium derivatives were synthesized, via appropriate synthetic routes, using imidazole, 1-methylimidazole and 2-phenyl-1-methylimidazole as key intermediates. The antibacterial activity of the prepared compounds was evaluated against: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella thipymurium using disk-diffusion and MIC methods. Crystal X-ray structures are reported for six compounds.
几种新的高功能化咪唑衍生物通过适当的合成途径合成,使用咪唑、1-甲基咪唑和 2-苯基-1-甲基咪唑作为关键中间体。采用纸片扩散法和 MIC 法评价了所制备化合物对大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌和鼠伤寒沙门氏菌的抗菌活性。报道了六种化合物的晶体 X 射线结构。