Cristofolini M, Recchia G, Boi S, Piscioli F, Bordin F, Baccichetti F, Carlassare F, Tamaro M, Pani B, Baburdi N
Division of Dermatology, Hospital of Santa Chiara, Trento, Italy.
Br J Dermatol. 1990 Apr;122(4):513-24. doi: 10.1111/j.1365-2133.1990.tb14728.x.
The monofunctional furocoumarins, the 6-methylangelicins, were tested for their antiproliferative activity with various animal models and for genotoxicity in micro-organisms and in mammalian cells. The most active compound was 6,4,4'-trimethylangelicin, which showed a high antiproliferative effect and reduced genotoxicity in comparison with 8-methoxypsoralen (8-MOP). Some of these compounds were also tested clinically by topical application on 17 patients with psoriasis. They appeared to be more active than 8-MOP in clearing psoriasis without inducing skin phototoxicity. The methylangelicins also caused skin pigmentation.
对单功能呋喃香豆素6-甲基白芷素进行了测试，观察其在各种动物模型中的抗增殖活性以及在微生物和哺乳动物细胞中的遗传毒性。活性最强的化合物是6,4,4'-三甲基白芷素，与8-甲氧基补骨脂素（8-MOP）相比，它具有很高的抗增殖作用且遗传毒性较低。其中一些化合物还对17名银屑病患者进行了局部应用的临床测试。在清除银屑病方面，它们似乎比8-MOP更具活性，且不会引起皮肤光毒性。甲基白芷素还会导致皮肤色素沉着。
