光化学疗法（补骨脂素加紫外线A，PUVA）与银屑病：8-甲氧基补骨脂素和8-甲氧基补骨脂素/5-甲氧基补骨脂素的比较

Photochemotherapy (PUVA) and psoriasis: comparison of 8-MOP and 8-MOP/5-MOP.

作者信息

Langner A, Wolska H, Kowalski J, Duralska H, Murawska E

出版信息

Int J Dermatol. 1976 Nov;15(9):688-9. doi: 10.1111/j.1365-4362.1976.tb01829.x.

DOI:10.1111/j.1365-4362.1976.tb01829.x

Abstract

Twenty-eight psoriatic patients received PUVA treatment (psoralen and long ultraviolet irradiations. Two preparations were used; 8-methoxypsoralen and a mixture of 5-methoxypsoralen and 8-methoxypsoralen. Both gave considerable improvement, but in 6 cases the lesions reappeared after 2 to 8 weeks, in spite of maintenance treatment. In this report, photochemotherapy of psoriasis was compared, using a UVA emitting lamp, 8-MOP, and a mixture of 8-MOP and 5-methoxypsoralen (5-MOP).

摘要

28名银屑病患者接受了补骨脂素加长波紫外线照射（PUVA）治疗。使用了两种制剂：8-甲氧基补骨脂素以及5-甲氧基补骨脂素与8-甲氧基补骨脂素的混合物。两种制剂均使病情有显著改善，但有6例患者尽管进行了维持治疗，皮损仍在2至8周后复发。在本报告中，使用发射UVA的灯、8-甲氧基补骨脂素（8-MOP）以及8-甲氧基补骨脂素与5-甲氧基补骨脂素（5-MOP）的混合物对银屑病的光化学疗法进行了比较。