Tian Ch, Liu Y-G, Yan J-K, Liu S-D, Zhao S-T, Wang H-W
Department of Kidney Transplantation, Second Hospital of Shandong University, Jinan, People's Republic of China.
Transplant Proc. 2013 Jan-Feb;45(1):157-62. doi: 10.1016/j.transproceed.2012.10.019.
The objective of this study was to investigate the roles of B- and T-lymphocyte attenuator (BTLA) and herpes virus entry mediator (HVEM) in acute and chronic transplant rejection and immune tolerance.
The expression patterns of BTLA/HVEM, interleukin (IL)-2, IL-4, IL-10, and interferon (IFN)-γ were analyzed among patients presenting with acute rejection episodes versus those maintaining stable renal function during therapy with mycophenolate mofetil (MMF), cyclosporine, or tacrolimus (FK506) plus prednisolone.
The expressions of BTLA/HVEM in the rejection group were obviously increased compared with the stable group (P < .05), followed by the elevation of serum levels of IL-2 and IFN-γ.
The expression levels of BTLA/HVEM can be considered to be early indicators of an acute rejection episode following kidney transplantation.
本研究旨在探讨B和T淋巴细胞衰减器（BTLA）及疱疹病毒进入介质（HVEM）在急性和慢性移植排斥反应及免疫耐受中的作用。
分析霉酚酸酯（MMF）、环孢素或他克莫司（FK506）加泼尼松龙治疗期间出现急性排斥反应的患者与肾功能维持稳定的患者之间BTLA/HVEM、白细胞介素（IL）-2、IL-4、IL-10和干扰素（IFN）-γ的表达模式。
与稳定组相比，排斥组中BTLA/HVEM的表达明显增加（P <.05），随后血清IL-2和IFN-γ水平升高。
BTLA/HVEM的表达水平可被视为肾移植后急性排斥反应发作的早期指标。
