Matejka M, Nell A, Kment G, Schein A, Leukauf M, Porteder H, Mailath G, Sinzinger H
University Department of Dentistry, University of Vienna.
Br J Oral Maxillofac Surg. 1990 Apr;28(2):89-91. doi: 10.1016/0266-4356(90)90128-8.
In 15 patients suffering from maxillofacial cancer with radiochemotherapy-induced oral mucositis the local application of prostaglandin E2 (PGE2) tablets, 0.5 mg four times a day at a 4-h interval was performed. Plasma determination of the bicyclo-prostaglandin E2 metabolite showed no significant amount of the locally applied substance in the circulation. It is claimed that for this particular indication, PGE2 is a potent locally acting compound without affecting circulating levels.
对15例患有颌面部癌症且因放化疗引起口腔黏膜炎的患者，局部应用前列腺素E2（PGE2）片剂，每天4次，每次0.5mg，间隔4小时。血浆中双环前列腺素E2代谢物的测定显示循环中未出现大量局部应用的该物质。据称，对于这一特定适应症，PGE2是一种有效的局部作用化合物，不会影响循环水平。
