Porteder H, Rausch E, Kment G, Watzek G, Matejka M, Sinzinger H
Dept. of Maxillo-Facial Surgery, University of Vienna, Austria.
J Craniomaxillofac Surg. 1988 Nov;16(8):371-4. doi: 10.1016/s1010-5182(88)80082-9.
Patients undergoing chemo- and/or radiotherapy for malignancies were often found to develop annoying inflammation of the oral mucosa. As prostaglandins are known to be cytoprotective. Prostaglandin E2 was given to 10 patients who received combined radio- and chemotherapy for oral neoplasms. Patients receiving PGE2 reported substantially less intense pain then those in the control group. Our statistically significant results indicate that topical treatment of side effects produced by combined radio- and chemotherapy of oral neoplasms with PGE2 holds promise and is clearly superior to conventional treatment modalities.
接受恶性肿瘤化疗和/或放疗的患者常常会出现令人烦恼的口腔黏膜炎症。由于已知前列腺素具有细胞保护作用，因此对10例接受口腔肿瘤联合放疗和化疗的患者给予了前列腺素E2。接受PGE2治疗的患者报告的疼痛强度明显低于对照组。我们具有统计学意义的结果表明，用PGE2局部治疗口腔肿瘤联合放化疗产生的副作用有前景，且明显优于传统治疗方式。
