Columbia University Medical Center/New York Presbyterian Hospital, New York, NY, USA.
J Am Coll Cardiol. 2013 Mar 19;61(11):1125-36. doi: 10.1016/j.jacc.2012.08.1039. Epub 2013 Jan 30.
Paravalvular leak (PVL) is a frequent complication of transcatheter aortic valve replacement (TAVR) and is seen at a much higher rate after TAVR than after conventional surgical aortic valve replacement. Recent reports indicating that PVL may be correlated with increased late mortality have raised concerns. However, the heterogeneity of methods for assessing and quantifying PVL, and lack of consistency in the timing of such assessments, is a hindrance to understanding its true prevalence, severity, and effect. This literature review is an effort to consolidate current knowledge in this area to better understand the prevalence, progression, and impact of post-TAVR PVL and to help direct future efforts regarding the assessment, prevention, and treatment of this troublesome complication.
瓣周漏（PVL）是经导管主动脉瓣置换术（TAVR）的常见并发症，在 TAVR 后比传统外科主动脉瓣置换术更为常见。最近的报告表明，PVL 可能与晚期死亡率增加有关，这引起了人们的关注。然而，评估和量化 PVL 的方法存在异质性，且此类评估的时间缺乏一致性，这阻碍了人们对其真实流行率、严重程度和影响的理解。本文献综述旨在整合该领域的现有知识，以更好地了解 TAVR 后 PVL 的流行率、进展和影响，并帮助指导未来评估、预防和治疗这一棘手并发症的工作。
