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[低血容量性低血压恢复期肺对生物胺的吸收与释放]

[Absorption and release of biogenic amines by the lung during the restorative period after hypovolemic hypotension].

作者信息

Trubina I E, Il'icheva R F, Volkov A V

出版信息

Biull Eksp Biol Med. 1990 Feb;109(2):132-4.

PMID:2337643
Abstract

The processes of serotonin and histamine absorption and release by the lungs were studied in dogs during 1 to 3.5 hour hypovolemic hypotension and during 24 hours after blood retains fusion. Absorption of biogenic amines by the lungs tended to increase in all the animals under hypovolemic hypotension. In the group of non-survivors the serotonin absorption by the lungs in the post-terminal period remained increased, while in the group of survivors it came down to normal soon, though the histamine release was increased. The above processes were aggravated in the group of animals whose lungs were affected by oleic acid. It resulted in the absorption of histamine instead of its release. The intensified absorption of biogenic amines by the lungs was accompanied by a quick fall in cardiac output, by the increase in resistance of systemic and pulmonary circulation.

摘要

在犬身上研究了在1至3.5小时的低血容量性低血压期间以及血液再灌注后24小时内肺对血清素和组胺的吸收与释放过程。在低血容量性低血压状态下,所有动物肺对生物胺的吸收均有增加趋势。在非存活组中,末期后肺对血清素的吸收仍持续增加,而在存活组中,尽管组胺释放增加,但肺对血清素的吸收很快恢复正常。上述过程在肺受油酸影响的动物组中加剧,导致组胺被吸收而非释放。肺对生物胺吸收增强伴随着心输出量迅速下降以及体循环和肺循环阻力增加。

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