Gabrielian S K, Srapionian R M, Abelian Zh G, Galoian A A
Biull Eksp Biol Med. 1990 Feb;109(2):147-8.
For more than 25 years the chemistry and the function of the protein-hormonal complexes (produced by magnocellular nuclei of human and same animals) have been studied. The methods of radioimmunological analyses (RIA) for the detection of new neuropecific cardioactive protein-hormone "K" (RHK) in rat organism with myocardial ischemia has been developed. Concentration of PHK in various regions of the brain by RIA a four days after the occlusion of the carotid artery has a sharp decrease. Particularly concentration of PHK decreases 100-fold in the cerebral cortex. At the same time the level of PHK content in the blood increased from 13 +/- 0.85 to 630 +/- 3.9 ng/ml. The maximum concentration of PHK shows a sharp rise in the spleen 200-fold of their original level. This distribution pattern implies that PHK may be of importance for peripheral tissues and to the scarring in heart neurosis zone.
25 多年来，人们一直在研究（由人类和某些动物的大细胞神经核产生的）蛋白质 - 激素复合物的化学性质和功能。已开发出用于检测大鼠心肌缺血机体中新型神经特异性心脏活性蛋白激素“K”（RHK）的放射免疫分析（RIA）方法。通过 RIA 检测，在颈动脉闭塞四天后，大脑各区域的 PHK 浓度急剧下降。特别是大脑皮层中的 PHK 浓度下降了 100 倍。与此同时，血液中 PHK 的含量水平从 13±0.85 纳克/毫升增加到 630±3.9 纳克/毫升。PHK 的最大浓度在脾脏中显示出急剧上升，达到其原始水平的 200 倍。这种分布模式表明，PHK 可能对周围组织以及心脏神经症区域的瘢痕形成具有重要意义。
