Srapionian R M
Usp Fiziol Nauk. 1996 Jul-Sep;27(3):78-83.
The method of radioimmune analysis was used to explore distribution of the cardioactive protein-hormone complexes extracted from oxen hypothalamus in rats with simulated myocardial infarction. The above cardial pathology is associated with devastation of these complexes in cerebrum, in particular, in the cortex of big hemispheres, hypothalamus, and cerebellum (12 to 130 times reduction). Simultaneously, the amount of immune-reactive protein-hormone complexes in some visceral organs and in blood was observed to intensively increase. The observations of 6-340 times of the above complexes suggest that they reach a new homeostatic level of concentration in the peripheral organs and tissue which should increase blood circulation in tissue, and in particular, in the myocardium. High biological role of the above complexes in regulation of the cardial and vascular functions and their anomalous multiplication in cardium enables us to suggest their possible participation of the complexes in reparation of a necrotic zone in myocardium.
采用放射免疫分析方法，研究从牛下丘脑提取的具有心脏活性的蛋白质 - 激素复合物在模拟心肌梗死大鼠体内的分布情况。上述心脏病变与这些复合物在大脑中的破坏有关，尤其是在大脑半球皮质、下丘脑和小脑中（减少了12至130倍）。同时，观察到一些内脏器官和血液中免疫反应性蛋白质 - 激素复合物的量显著增加。上述复合物增加了6 - 340倍的观察结果表明，它们在外周器官和组织中达到了新的稳态浓度水平，这应该会增加组织中的血液循环，尤其是心肌中的血液循环。上述复合物在心脏和血管功能调节中具有很高的生物学作用，并且它们在心脏中的异常增殖使我们能够推测这些复合物可能参与心肌坏死区域的修复。
