Akhlynina T V, Gulak P V, Serebriakova N V, Rozenkrants A A, Sobolev A S
Biull Eksp Biol Med. 1990 Feb;109(2):150-2.
To minimize the side effect of porphyrin photosensitizers and to reduce their active concentration, chlorine e6 was conjugated with concanavalin A. Photodynamic action of chlorine e6 and concanavalin A-chlorine e6 conjugate has been studied in human skin embryonic fibroblasts. The conjugate appeared to be 5 times more effective as compared to chlorine e6 due to concanavalin A-chlorine e6 endocytosis into intracellular compartments.
为了将卟啉光敏剂的副作用降至最低并降低其活性浓度，将氯e6与伴刀豆球蛋白A偶联。已在人皮肤胚胎成纤维细胞中研究了氯e6和伴刀豆球蛋白A-氯e6偶联物的光动力作用。由于伴刀豆球蛋白A-氯e6内吞进入细胞内区室，该偶联物的效果似乎比氯e6高5倍。
