Synthesis of a series of maltotriose phosphates with an evaluation of the utility of a fluorous phosphate protecting group.

A series of methyl maltotrioside phosphates were synthesized for application in the determination of the actual molecular substrate of the Lafora enzyme involved in Lafora disease. Several different synthetic routes were applied for the successful synthesis of six methyl maltotrioside phosphate regioisomers. The utility of a new fluorous phosphate protecting group was also evaluated, but its utility was found to be limited in this particular late stage introduction.