阴离子表面活性剂与脂质体相互作用的分子动力学。

Molecular dynamics of the interaction of anionic surfactants with liposomes.

机构信息

Laboratory for Surface Science and Technology, Department of Chemistry, University of Maine, Orono, ME 04469, United States.

出版信息

Colloids Surf B Biointerfaces. 2013 May 1;105:173-9. doi: 10.1016/j.colsurfb.2012.12.045. Epub 2013 Jan 5.

DOI:10.1016/j.colsurfb.2012.12.045

PMID:23376744

Abstract

The time dependent molecular interactions of sodium dodecyl sulfate (SDS) with dipalmitoylphosphatidylcholine (DPPC) liposomes were studied using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy. In particular, the ATR spectra provided information on the dynamic amount of SDS incorporated and DPPC expelled in the DPPC structure along with structural information on the molecular nature of the SDS/DPPC assemblies. It was found that the uptake of SDS was always mirrored by the ejection of DPPC molecules from the liposomes and that the incorporation of SDS followed two routes; SDS intercalated into the DPPC liposomes and SDS was bound electrostatically to the charged surface of the DPPC liposome.

摘要

使用衰减全反射傅里叶变换红外（ATR-FTIR）光谱研究了十二烷基硫酸钠（SDS）与二棕榈酰磷脂酰胆碱（DPPC）脂质体之间随时间变化的分子相互作用。特别是，ATR 光谱提供了有关 SDS 掺入量和 DPPC 从 DPPC 结构中排出量的动态信息，以及 SDS/DPPC 组装体的分子性质的结构信息。结果发现，SDS 的摄取总是伴随着 DPPC 分子从脂质体中排出，并且 SDS 的掺入遵循两种途径；SDS 插入 DPPC 脂质体中，SDS 通过静电结合到 DPPC 脂质体的带电表面上。